![]() Our assemblies correct substantial errors, add missing sequence in some of the best historical reference genomes, and reveal biological discoveries. We confirm that long-read sequencing technologies are essential for maximizing genome quality, and that unresolved complex repeats and haplotype heterozygosity are major sources of assembly error when not handled correctly. ![]() Here we present lessons learned from generating assemblies for 16 species that represent six major vertebrate lineages. To address this issue, the international Genome 10K (G10K) consortium 5, 6 has worked over a five-year period to evaluate and develop cost-effective methods for assembling highly accurate and nearly complete reference genomes. However, such assemblies are available for only a few non-microbial species 1, 2, 3, 4. ![]() High-quality and complete reference genome assemblies are fundamental for the application of genomics to biology, disease, and biodiversity conservation. Nature volume 592, pages 737–746 ( 2021) Cite this article Towards complete and error-free genome assemblies of all vertebrate species
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